Kennedy, who previously ran as an independent candidate for the presidency, now oversees critical health organizations including the CDC, FDA, and NIH, along with a vast workforce of around 80,000 employees. His bid for confirmation saw opposition from notable figures, including his own cousin, Caroline Kennedy, who argued against his suitability due to his anti-vaccine stances. Despite this, certain Republicans praised his efforts to address health issues like food additives and big pharmaceutical practices.

During his confirmation hearings, Kennedy faced intense scrutiny over his promotion of health misinformation and views on abortion, which he attempted to navigate by aligning with Trump's policy approach of state control over abortion rights. His confirmation follows that of former Arizona Rep. Tulsi Gabbard as Director of National Intelligence, highlighting the administration's push to rapidly staff the cabinet.

Kennedy's agenda for the health sector includes addressing food safety, pharmaceuticals, and vaccinations, raising questions about his potential influence on to American health policy during a time of division. Critics worry about his ability to effectively lead health initiatives, especially given his past remarks and association with groups questioning vaccine safety. As the Senate prepares for further confirmations of Trump's nominees, Kennedy's role is under close watch to see how he will tackle these pressing health challenges.