Governor Josh Shapiro stated that state emergency management services and police have been dispatched to the scene. U.S. Senator John Fetterman reported witnessing the active search and rescue efforts, emphasizing the severity of the incident. David B. Burritt, CEO of US Steel, confirmed the company is collaborating with authorities to investigate the explosion, describing the plant as "stable" while acknowledging that the situation is still developing. Clairton's Mayor Richard Lattanzi conveyed his distress over the incident, referring to it as "a sad day for Clairton."

The Clairton Coke Works plant has faced scrutiny for environmental issues and has accrued significant fines for various pollution violations over the years. Recent penalties include nearly $2 million from the Allegheny County Health Department for operational problems and a $2.2 million fine this year for exceeding regulatory limits on hydrogen sulfide emissions. Pennsylvania's health officials had earlier fined US Steel $4.7 million in 2022 for failing to operate a required pollution control device. Authorities continue to monitor the air quality and encourage local residents to remain indoors.