In brief
Prince Frederik, who founded a foundation to combat POLG disorder, passed away after battling the debilitating effects of the disease.
Prince Frederik of Luxembourg, a young royal known for his advocacy work, has passed away at the age of 22 from complications related to a rare genetic disorder called POLG disease. His father, Prince Robert, confirmed the news in a statement via the POLG Foundation, which Frederik co-founded to raise awareness about the genetic condition caused by mutations in the POLG gene.Discovered at age 14, Frederik's diagnosis of POLG, or polymerase gamma disease, unveiled a life-long challenge marked by gradual physical decline. Estimates from the United Mitochondrial Disease Foundation indicate that approximately one in 10,000 individuals is diagnosed with this disorder, which impacts mitochondrial function necessary for cellular energy production. Symptoms range from seizures and coordination difficulties to multi-organ dysfunctions.Described by experts as a particularly cruel and progressive form of mitochondrial disease, POLG attacks various bodily systems leading to serious health impacts, according to Sir Doug Turnbull, an esteemed neurology professor involved with the POLG Foundation’s advisory board.Frederik was more than just a royal; he was a passionate advocate who poured his energy into raising awareness about POLG disease. He initiated research projects using his own DNA for study purposes, created educational films, and even designed a clothing line to fund further research efforts.Born in Aix-en-Provence, France, and raised in Switzerland, Frederik had a love for pop culture, particularly the American television series “The Office.” By the end of his life, he found himself hospitalized with severe pneumonia and additional infections, yet he retained joy in his final moments, marveling at the view of the Eiffel Tower's lights and asking for photos of sunsets, showcasing an indomitable spirit in his battle against his illness.A second cousin to Luxembourg’s upcoming heir, Prince Guillaume, Frederik's advocacy work sheds light on the struggles faced by those with rare genetic diseases. In his foundation’s film, he remarked on the childhood dreams inherent to youth, reflecting on how his understanding of POLG changed over time as his health limitations gradually confined his world.The Luxembourg royal family mourns the loss of a young prince who dedicated his life to a cause larger than himself, leaving behind a legacy of awareness and hope for others impacted by POLG disorder.
