More than 35 people have been killed in Israeli strikes and gunfire since the early hours of Saturday morning, hospital sources in Gaza say.
A strike on a house in central Gaza left at least 11 people dead - more that half of them women and children - according to officials at al-Ahli Arab hospital in Gaza City.
Health workers said nine members of the same family were among those killed in an Israeli strike on the Nuseirat refugee camp, and at least six people are reported to have been killed while seeking aid in central and southern Gaza.
It comes a day after Israeli PM Benjamin Netanyahu told the United Nations that Israel must finish the job against Hamas.
The Israeli air force says it has hit approximately 120 targets across the Strip since Friday - including, the military says, buildings used by terror groups, terror operatives and other infrastructure.
There has been no let up in Israel's recent expanded ground offensive against Hamas, which is now mainly focused on Gaza City, where Israel says is the last stronghold of the armed group.
Hundreds of thousands of residents have fled the territory's biggest urban centre, where a famine was confirmed last month by a UN-backed body. But hundreds of thousands more remain there in dire humanitarian conditions, with health and other essential services collapsing.
Many civilians are caught between Israeli airstrikes and dire humanitarian conditions, declaring their despair. They tell us go there, then come back here... Where should we go? said a local resident amid ongoing chaos.
International calls for a ceasefire have intensified amidst the violence and the dire humanitarian situation continues to deteriorate.
The Israeli military's operations have allegedly resulted in over 65,549 deaths in Gaza since the campaign began. As the conflict escalates, there remains urgent pressure for negotiations and a potential resolution.