Bono, whose real name is Paul David Hewson, is already celebrated with France's highest cultural distinction and an honorary knighthood for his relentless work against poverty and support for HIV/AIDS initiatives. Wintour, the editor-in-chief of Vogue since 1988, is a key player in the fashion realm, having raised over $20 million for AIDS research and advocated for the arts in light of funding cuts in the UK. Among other honored figures this year is ex-Secretary of State Hillary Clinton, who accepts the award just prior to the inauguration of her political rival, Donald Trump.

The list of honorees features various cultural and humanitarian luminaries, including actors Denzel Washington and Michael J. Fox, football superstar Lionel Messi, and celebrated chef José Andrés, known for his impactful World Central Kitchen organization that feeds communities in crisis. The awards also extend posthumously to influential figures like civil rights leader Fannie Lou Hamer and former Attorney General Robert F. Kennedy.

The Presidential Medal of Freedom was established by President John F. Kennedy and is granted at the discretion of the sitting president, advised by an external panel. Notable past recipients include gymnast Simone Biles, actress Michelle Yeoh, and Apple co-founder Steve Jobs, underscoring the medal's tradition of honoring outstanding achievements across various fields.